Duvaldestin P, Desmonts J M
Ann Anesthesiol Fr. 1976;17(3):315-20.
The authors attempt to explain halothane-induced hepatitis by a mechanism involving direct toxicity of a metabolite of this halogen compound. This implies a genetically determined metabolic disturbance or an increase in metabolic rate through previous enzyme induction (repeated anesthesia with halogen compounds).
作者试图通过一种涉及该卤代化合物代谢产物直接毒性的机制来解释氟烷性肝炎。这意味着存在一种由基因决定的代谢紊乱，或者是由于先前的酶诱导作用（反复使用卤代化合物进行麻醉）导致代谢率增加。
