Tsap L V, Goldgof D B, Sarkar S, Powers P S
Department of Computer Science and Engineering, University of South Florida, Tampa 33620, USA.
IEEE Trans Med Imaging. 1998 Aug;17(4):620-33. doi: 10.1109/42.730406.
In this paper a method for the objective assessment of burn scars is proposed. The quantitative measures developed in this research provide an objective way to calculate elastic properties of burn scars relative to the surrounding areas. The approach combines range data and the mechanics and motion dynamics of human tissues. Active contours are employed to locate regions of interest and to find displacements of feature points using automatically established correspondences. Changes in strain distribution over time are evaluated. Given images at two time instances and their corresponding features, the finite element method is used to synthesize strain distributions of the underlying tissues. This results in a physically based framework for motion and strain analysis. Relative elasticity of the burn scar is then recovered using iterative descent search for the best nonlinear finite element model that approximates stretching behavior of the region containing the burn scar. The results from the skin elasticity experiments illustrate the ability to objectively detect differences in elasticity between normal and abnormal tissue. These estimated differences in elasticity are correlated against the subjective judgments of physicians that are presently the practice.
本文提出了一种烧伤瘢痕客观评估方法。本研究中开发的定量测量方法提供了一种客观方式,用以计算烧伤瘢痕相对于周围区域的弹性特性。该方法结合了距离数据以及人体组织的力学和运动动力学。使用主动轮廓来定位感兴趣区域,并利用自动建立的对应关系找到特征点的位移。评估应变分布随时间的变化。给定两个时刻的图像及其相应特征,采用有限元方法合成底层组织的应变分布。这形成了一个基于物理的运动和应变分析框架。然后,通过迭代下降搜索,找到最能近似包含烧伤瘢痕区域拉伸行为的最佳非线性有限元模型,从而恢复烧伤瘢痕的相对弹性。皮肤弹性实验结果表明,该方法能够客观检测正常组织与异常组织之间的弹性差异。这些估计出的弹性差异与目前医生的主观判断相关。