Singh V, Garg A N
Department of Chemistry, Nagpur University, India.
Biol Trace Elem Res. 1998 Summer;64(1-3):237-45. doi: 10.1007/BF02783340.
Fourteen minor (Na, K, P, Fe) and trace (Br, Co, Cr, Cs, Hg, Rb, Sb, Se, Sr, Zn) elements have been determined in pre- and postoperative blood samples of 10 breast-cancer-affected. Indian women and compared with controls. The study showed elevation of Cr, Hg, Fe, Rb, Sb, and Zn and lowering of Se, K, P, and Sr contents in the blood of cancer patients. Most elemental contents in pre- and postoperative stages remain unaltered except Br, Co, and Sb. Statistical significance of Fe, Se, Zn, and Hg levels has been tested by box plots. Lowering of Se in blood (-54.4%) is correlated with its enhancement in cancerous breast tissue (94.7%) of various clinical stages. Se/Zn and Se/Fe ratios are lowered in the blood of cancer patients, whereas Na/K ratio is only marginally enhanced. An attempt has been made to correlate Se levels with the dietary intake and breast cancer risk vis-a-vis American and Japanese women.
已对10名患乳腺癌的印度女性术前和术后的血样中的14种微量元素（钠、钾、磷、铁）和痕量元素（溴、钴、铬、铯、汞、铷、锑、硒、锶、锌）进行了测定，并与对照组进行了比较。研究表明，癌症患者血液中的铬、汞、铁、铷、锑和锌含量升高，而硒、钾、磷和锶含量降低。除溴、钴和锑外，术前和术后阶段的大多数元素含量保持不变。通过箱线图检验了铁、硒、锌和汞水平的统计学显著性。血液中硒含量降低（-54.4%）与其在不同临床阶段癌性乳腺组织中的含量升高（94.7%）相关。癌症患者血液中的硒/锌和硒/铁比值降低，而钠/钾比值仅略有升高。已尝试将硒水平与美国和日本女性的饮食摄入量及乳腺癌风险相关联。
