Ehmann W D, Markesbery W R, Alauddin M, Hossain T I, Brubaker E H
Neurotoxicology. 1986 Spring;7(1):195-206.
Instrumental neutron activation analysis has been used to determine the concentrations of 16 elements in selected brain regions and separated gray- and white-matter specimens from histologically verified Alzheimer's disease (AD) and age-matched control patients. Significantly different (p less than 0.05) mean concentrations of Br, Cl, Cs, Hg, N, Na, P, and Rb were observed in AD bulk brain samples compared to controls, while no significant differences were observed for Ag, Co, Cr, Fe, K, Sb, Sc, and Se. The differences that are most persistent and largest in magnitude for the pooled bulk samples, males and females, left and right hemispheres, and separated gray and white matter are the elevation of Br and Hg and the depletion of Rb in AD compared to controls. Significant interelement correlations for the latter elements in both AD and control brains are also documented. Based on these studies, the possibility of an etiological role for trace elements in AD clearly deserves further investigation.
仪器中子活化分析已用于测定经组织学证实的阿尔茨海默病（AD）患者及年龄匹配的对照患者特定脑区以及分离出的灰质和白质标本中16种元素的浓度。与对照组相比，AD脑总体样本中溴（Br）、氯（Cl）、铯（Cs）、汞（Hg）、氮（N）、钠（Na）、磷（P）和铷（Rb）的平均浓度存在显著差异（p小于0.05），而银（Ag）、钴（Co）、铬（Cr）、铁（Fe）、钾（K）、锑（Sb）、钪（Sc）和硒（Se）未观察到显著差异。对于合并的总体样本、男性和女性、左右半球以及分离出的灰质和白质而言，最持久且幅度最大的差异是与对照组相比，AD中溴和汞升高以及铷减少。AD和对照脑中后几种元素的显著元素间相关性也有记录。基于这些研究，微量元素在AD病因学中的作用可能性显然值得进一步研究。
