Nomura K, Miyagawa S, Harada H, Kitamura H, Seki H, Shimada R, Kobayashi A, Noike T, Kawasaki S
First Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Dig Surg. 1998;15(1):21-4. doi: 10.1159/000018581.
The doubling times of liver metastases were calculated in order to clarify their usefulness in predicting the presence of residual cancer in the abdominal cavity in patients who had undergone curative resection of primary colorectal cancer.
Tumor doubling times were calculated retrospectively in 22 patients by serial measurement of the size of their liver metastases.
Patients with a tumor doubling time of less than 92.4 days had a significantly poorer prognosis than those with a doubling time more than or equal to 92.4 days (p < 0.05). Local recurrence or peritoneal dissemination was significantly more likely to occur when the tumor doubling time was less than 92.4 days than when it was more than or equal to 92.4 days (p < 0.01).
The doubling time of hepatic metastases in patients with colorectal carcinoma may be a useful prognostic indicator, with patients who have a shorter tumor doubling time carrying a greater risk of residual primary cancer in the abdominal cavity.
计算肝转移瘤的倍增时间，以阐明其在预测接受原发性结直肠癌根治性切除的患者腹腔内残留癌存在情况方面的作用。
对22例患者的肝转移瘤大小进行系列测量，回顾性计算肿瘤倍增时间。
肿瘤倍增时间小于92.4天的患者预后明显比倍增时间大于或等于92.4天的患者差（p<0.05）。肿瘤倍增时间小于92.4天时，局部复发或腹膜播散的发生显著高于倍增时间大于或等于92.4天时（p<0.01）。
结直肠癌患者肝转移瘤的倍增时间可能是一个有用的预后指标，肿瘤倍增时间较短的患者腹腔内残留原发性癌的风险更大。
