Gentry P A, Black W D
Am J Vet Res. 1976 Nov;37(11):1349-52.
The effects of intravenously administered commercial pentobarbital sodium, pentobarbital sodium in saline solution, 40% propylene glycol in saline solution, 10% ethanol in saline solution, and saline solution on erythrocyte fragility and blood coagulation variables were studied in the dog. The pentobarbital solution and the 40% propylene glycol caused erythrocyte lysis and obvious hemoglobin release into the plasma. They also caused a shortening of the whole blood clotting time and partial thromboplastin time tests, evidence of increased procoagulant activity involving the intrinsic coagulation system. Alterations in these variables were not noticed after pentobarbital sodium in saline solution, 10% ethanol in saline solution, and saline solution injections. Changes were not noticed in the extrinsic coagulation system or in platelet function.
研究了静脉注射市售戊巴比妥钠、生理盐水溶液中的戊巴比妥钠、生理盐水溶液中的40%丙二醇、生理盐水溶液中的10%乙醇以及生理盐水溶液对犬红细胞脆性和血液凝固变量的影响。戊巴比妥溶液和40%丙二醇导致红细胞溶解，并使血红蛋白明显释放到血浆中。它们还导致全血凝固时间和部分凝血活酶时间试验缩短，这证明涉及内源性凝血系统的促凝活性增加。注射生理盐水溶液中的戊巴比妥钠、生理盐水溶液中的10%乙醇以及生理盐水溶液后，未观察到这些变量的变化。在外源性凝血系统或血小板功能方面未发现变化。
