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[促肾上腺皮质激素释放素对多巴胺缺乏犬行为影响的纹状体机制]

[Striatal mechanisms of corticoliberin effect on the behavior of dogs with dopamine deficiency].

作者信息

Voĭlokova N L, Suvorov N F, Rakitskaia V V, Shaliapina V G

机构信息

Institute of Physiology of the Russian Acad. Sci., St. Petersburg, Russia.

出版信息

Ross Fiziol Zh Im I M Sechenova. 1998 Aug;84(8):728-34.

PMID:9845889
Abstract

Interaction between dopaminergic and corticoliberinergic integrative systems in the process of situation alimentary conditioning, was studied in dogs with chemotrodes indwelled in the caudate nucleus head. Following the CRF administration, the cortisol and catecholamine levels were determined in the blood of intact dogs and in the dogs with 6-OHDA impairment of the substantia nigra. The findings suggest that an interaction between the CRF and dopaminergic systems occurs in the neostriatum.

摘要

在食源性条件反射过程中,对在尾状核头部植入化学电极的犬类中多巴胺能和促肾上腺皮质激素释放因子能整合系统之间的相互作用进行了研究。给予促肾上腺皮质激素释放因子后,测定了正常犬以及黑质经6-羟基多巴胺损伤的犬血液中的皮质醇和儿茶酚胺水平。研究结果表明,促肾上腺皮质激素释放因子和多巴胺能系统在新纹状体中发生相互作用。

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