[四氧嘧啶糖尿病小鼠肝脏中磷脂合成的研究]
[Study of phospholipid synthesis in liver of mice with alloxan diabetes].
作者信息
Saprykina E V, Kozlov Iu A, Sosnina N V, Baĭkov A N, Novitskiĭ V V
机构信息
Central Research Laboratory, Siberian Medical University, Tomsk.
出版信息
Vopr Med Khim. 1998 Jul-Aug;44(4):376-9.
The essential decrease of the rate of turnover of phosphatidic acids (PA), polyglycerophosphates (PGP) and their lysoderivatives (LPGP), sphinigomyelin (SM) and lysophosphatidylcholine (LPC), phosphatidyletnanolamine (PEA) was found in male mice of BALB/c strain with subacute alloxan diabetes (glucose concentration in the blood was not less than 14 mmol/l) during examination of phospholipid metabolism in the liver by the rate of 3H-acetate and 14C-palmitate incorporation into corresponding chromatographic phospholipid fractions. On the contrary, turnover of phosphatidilcholine (PC) significantly increased. The of main structural phospholipid components of hepatocyte cellular membranes--PEA and PC--were found to be decreased by 41 and 32%, respectively. LPGP and PA levels decreased to a lesser extent. The level of PGP, SM, phosphatidylinositol and LPG did not differ from the control level.
在用3H-乙酸盐和14C-棕榈酸盐掺入相应色谱磷脂组分的速率来检测肝脏磷脂代谢的过程中，发现BALB/c品系的雄性小鼠患有亚急性四氧嘧啶糖尿病（血糖浓度不低于14 mmol/l）时，磷脂酸（PA）、聚甘油磷酸酯（PGP）及其溶血衍生物（LPGP）、鞘磷脂（SM）和溶血磷脂酰胆碱（LPC）、磷脂酰乙醇胺（PEA）的周转率显著下降。相反，磷脂酰胆碱（PC）的周转率显著增加。肝细胞细胞膜的主要结构磷脂成分——PEA和PC——分别下降了41%和32%。LPGP和PA水平下降幅度较小。PGP、SM、磷脂酰肌醇和LPG的水平与对照水平没有差异。
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