合成以脂多糖A类似物作为合成疫苗免疫佐剂的Tn、唾液酸化Tn和HIV-1衍生肽抗原偶联物。
Synthesis of Tn, sialyl Tn and HIV-1-derived peptide antigen conjugates having a lipid A analog as an immunoadjuvant for synthetic vaccines.
作者信息
Miyajima K, Nekado T, Ikeda K, Achiwa K
机构信息
School of Pharmaceutical Sciences, University of Schizuoka, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1998 Nov;46(11):1676-82. doi: 10.1248/cpb.46.1676.
PMID:9845951
Abstract
Conjugates (3-5) of Tn, sialyl Tn and HIV-1-derived peptide antigen with a N-tetradecanoyl L-serine-beta-alanine-containing D-glucosamine derivative, structurally related to lipid A, as an immunoadjuvant for the development of totally synthetic vaccines against cancers or HIV were synthesized. The mitogenic activity of compounds 3, 4 and 5 was stronger than that of lipid A analogs (1, 2).
摘要
合成了Tn、唾液酸Tn和HIV-1衍生肽抗原与一种含N-十四烷酰-L-丝氨酸-β-丙氨酸的D-葡糖胺衍生物（其结构与脂多糖A相关）的缀合物（3-5），用作开发针对癌症或HIV的全合成疫苗的免疫佐剂。化合物3、4和5的促有丝分裂活性强于脂多糖A类似物（1、2）。
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