sTn双C-糖苷类似物的合成
Synthesis of double C-glycoside analogue of sTn.
作者信息
Ress Dino K, Baytas Sultan N, Wang Qun, Muñoz Eva M, Tokuzoki Kazuo, Tomiyama Hiroshi, Linhardt Robert J
机构信息
Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.
出版信息
J Org Chem. 2005 Sep 30;70(20):8197-200. doi: 10.1021/jo050691n.
Abstract
A sTn double C-glycoside, sTn analogue 2, was synthesized using samarium chemistry developed in our laboratory. Complications in the oxidation reaction affording aldehyde acceptor were overcome by double protection of amide and the use of a room-temperature ionic liquid as solvent. Studies are underway to conjugate the sTn double C-glycoside hapten 2 to KLH carrier protein for biological evaluation as a vaccine.
摘要
利用我们实验室开发的钐化学方法合成了一种sTn双C-糖苷，即sTn类似物2。通过酰胺的双重保护以及使用室温离子液体作为溶剂，克服了生成醛受体的氧化反应中的并发症。目前正在进行研究，将sTn双C-糖苷半抗原2与钥孔血蓝蛋白（KLH）载体蛋白偶联，作为疫苗进行生物学评估。
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