人类免疫缺陷病毒感染患者抑郁症的治疗
Treatment of depression in HIV-infected patients.
作者信息
Cazzullo C L, Bessone E, Bertrando P, Pedrazzoli L, Cusini M
机构信息
University of Milan, Italy.
出版信息
J Psychiatry Neurosci. 1998 Nov;23(5):293-7.
BACKGROUND
Pharmacological treatment of depression in HIV-infected patients has been found to be effective. This study assessed the efficacy and feasibility of treatment with fluoxetine and the best method of administering the drug to patients with HIV infection.
METHODS
Sixteen seropositive and 16 seronegative patients, equally matched for age and sex, who had Hamilton Rating Scale for Depression scores of at least 16 and who received at least 20 mg/d of fluoxetine for 8 weeks were studied.
RESULTS
Depression was alleviated in both groups. However, improvement in the seropositive patients occurred later.
INTERPRETATION
The results confirm the effectiveness of fluoxetine in treating depression in people with HIV infection. The lack of adverse effects makes this treatment particularly suitable, especially because seronegative people take longer to respond to treatment.
背景
已发现抗逆转录病毒治疗对感染HIV的患者的抑郁症有效。本研究评估了氟西汀治疗的疗效和可行性，以及向HIV感染患者给药的最佳方法。
方法
研究了16名血清反应阳性和16名血清反应阴性的患者，他们在年龄和性别上匹配，汉密尔顿抑郁量表评分至少为16分，并且接受至少20mg/d的氟西汀治疗8周。
结果
两组的抑郁症均得到缓解。然而，血清反应阳性患者的改善出现得较晚。
解读
结果证实了氟西汀治疗HIV感染患者抑郁症的有效性。缺乏不良反应使得这种治疗特别合适，尤其是因为血清反应阴性的人对治疗的反应时间更长。
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