Lyketsos C G, Hoover D R, Guccione M, Dew M A, Wesch J, Bing E G, Treisman G J
Department of Psychiatry, School of Medicine, Johns Hopkins University, Baltimore, MD 21287-5371, USA.
Soc Psychiatry Psychiatr Epidemiol. 1996 Jun;31(3-4):212-9. doi: 10.1007/BF00785770.
The objective of this study was to describe the prevalence and course of depressive symptoms before AIDS in HIV-infected homosexual men. A descriptive and comparative analysis of data from HIV-infected and -uninfected homosexual men in the Multicenter AIDS Cohort Study was performed. The Center for Epidemiologic Studies Depression Scale (CES-D) was the primary measure of depressive symptoms. The prevalence of depressive symptoms and CES-D caseness estimates in the AIDS-free HIV-infected homosexual men were stable over time. Small differences between HIV seropositive and seronegative men were detected on the CES-D and on three of its subscales. These were mostly accounted for by less hope, and by more fearfulness, insomnia, and anorexia in the seropositive cohort. We concluded that there does not appear to be an overall increase in depressive symptoms in HIV-infected homosexual men from the time of infection until prior to AIDS. However, this group of men consistently report specific depressive symptoms more often. Implications of these findings for the clinical care of HIV-infected patients is discussed.
本研究的目的是描述感染HIV的男同性恋者在患艾滋病之前抑郁症状的患病率及病程。对多中心艾滋病队列研究中感染HIV和未感染HIV的男同性恋者的数据进行了描述性和对比分析。流行病学研究中心抑郁量表（CES-D）是抑郁症状的主要测量工具。未患艾滋病的感染HIV的男同性恋者中抑郁症状的患病率及CES-D病例数估计随时间保持稳定。在CES-D及其三个子量表上，检测到HIV血清阳性和血清阴性男性之间存在微小差异。这些差异主要是由于血清阳性队列中希望更少，恐惧、失眠和厌食更多。我们得出结论，从感染HIV到患艾滋病之前，感染HIV的男同性恋者的抑郁症状似乎并未总体增加。然而，这组男性始终更频繁地报告特定的抑郁症状。讨论了这些发现对HIV感染患者临床护理的意义。
