Stephens B G, Coleman D E, Baselt R C
Chemical Toxicology Institute, Foster City, CA, USA.
J Forensic Sci. 1998 Nov;43(6):1252-3.
A 43-year-old male psychiatric outpatient died within hours of ingesting as much as 600 mg of olanzapine, a newer antipsychotic agent related to clozapine. Analysis of postmortem blood and urine by gas chromatography with nitrogen-selective detection yielded olanzapine concentrations of 1238 and 6987 micrograms/L, respectively, greatly in excess of levels expected following therapeutic administration of the drug. Based on the toxicology findings, the decedent's known history of suicide attempts, and the circumstances surrounding the death, this case was ruled a suicide by olanzapine overdosage.
一名43岁的男性精神科门诊患者在服用多达600毫克奥氮平（一种与氯氮平相关的新型抗精神病药物）数小时内死亡。通过气相色谱-氮选择性检测对死后血液和尿液进行分析，奥氮平浓度分别为1238微克/升和6987微克/升，大大超过该药物治疗给药后预期的水平。根据毒理学结果、死者已知的自杀未遂史以及死亡时的情况，该病例被判定为奥氮平过量服用自杀。
