Cohen L G, Fatalo A, Thompson B T, Di Centes Bergeron G, Flood J G, Poupolo P R
Pediatric Psychopharmacology Unit, Department of Psychiatry, Massachusetts, USA.
Ann Emerg Med. 1999 Aug;34(2):275-8. doi: 10.1016/s0196-0644(99)70243-x.
Olanzapine, a new atypical antipsychotic drug, has been prescribed in the treatment of schizophrenia and psychotic mood disorders for approximately 2.3 million patients worldwide. Considering the increase in olanzapine prescriptions and the increased risk of suicide in this patient population, the number of reported cases of olanzapine overdose may be expected to increase. This report describes the clinical course and serum concentrations in a patient who consumed an olanzapine overdose (800 mg). Profound central nervous system depression and tachycardia without arrhythmia occurred within 2 hours after the ingestion. Additional clinical findings (ie, fever, mutism, agitation, dystonia, akathisia, elevated creatine kinase, and increased leukocyte count) were similar to those of neuroleptic malignant syndrome. After intubation, gut decontamination, and supportive care, the patient recovered and was discharged.
奥氮平是一种新型非典型抗精神病药物，全球约有230万患者使用它来治疗精神分裂症和伴有精神病性症状的心境障碍。鉴于奥氮平处方量的增加以及该患者群体自杀风险的上升，预计奥氮平过量服用的报告病例数可能会增加。本报告描述了一名服用过量奥氮平（800毫克）患者的临床病程及血清浓度。摄入药物后2小时内出现了严重的中枢神经系统抑制和无心律失常的心动过速。其他临床发现（如发热、缄默、激越、肌张力障碍、静坐不能、肌酸激酶升高和白细胞计数增加）与抗精神病药恶性综合征相似。经过插管、肠道去污和支持治疗后，患者康复出院。
