Aubard Y, Rogez S, Darde M L, Fermeaux V, Servaud M, Lienhardt A
Gynecology Department, CHU Limoges, France.
Eur J Obstet Gynecol Reprod Biol. 1998 Oct;80(2):275-8. doi: 10.1016/s0301-2115(98)00107-9.
We report the first case of a double maternal seroconversion for Toxoplasma gondii (TG) and cytomegalovirus (CMV) diagnosed during pregnancy.
One case is reported of a female patient referred for seroconversion in response to TG in the 27th week of gestation. A search for foetal involvement revealed signs of non-specific foetal infection without any TG-related lesions. Tests were carried out for another foeto-maternal infectious disease and maternal seroconversion in response to CMV was discovered with virus in the amniotic fluid. The foetus developed hydrocephalus and intracranial calcifications and the pregnancy was terminated at the parents' request. CMV-induced multiple organ involvement without any signs of Toxoplasma gondii-related involvement were noted in the foetus.
This case indicates that a search should be made for another infectious disease likely to involve the foetus when non-specific signs of infection in the foetus are present, even though maternal seroconversion has been recognized.
我们报告了首例在孕期诊断出的孕妇弓形虫（TG）和巨细胞病毒（CMV）双重血清学转换病例。
报告了一例女性患者，在妊娠第27周因弓形虫血清学转换前来就诊。对胎儿受累情况的检查发现了非特异性胎儿感染迹象，但无任何与弓形虫相关的病变。针对另一种母婴传染病进行了检测，发现孕妇对巨细胞病毒发生血清学转换，且羊水内存在该病毒。胎儿出现脑积水和颅内钙化，应父母要求终止了妊娠。胎儿出现巨细胞病毒引起的多器官受累，无任何弓形虫相关受累迹象。
该病例表明，即使已确认孕妇血清学转换，但当胎儿存在非特异性感染迹象时，仍应排查另一种可能累及胎儿的传染病。
