Skovsted I C, Christensen M, Breinholt J, Mortensen S B
Health Care Discovery, Novo Nordisk A/S, Bagsvaerd, Denmark.
Cell Mol Biol (Noisy-le-grand). 1998 Nov;44(7):1159-63.
Dicarbonyl compounds are supposed to be reactive intermediates in the non-enzymatic glycation of proteins. A process that eventually could lead to the development of late diabetic complications. Glyoxal lysine dimer (GOLD) and methylglyoxal lysine dimer (MOLD) have previously been described as such reactive dicarbonyls. Here a new compound 3-deoxyglucosone lysine dimer (DOLD), a cross-link resulting from the reaction between hippuryl-lysine and 3-deoxyglucosone, has been isolated by HPLC and the structure determined by mass spectrometry and NMR.
二羰基化合物被认为是蛋白质非酶糖基化过程中的反应性中间体。这一过程最终可能导致晚期糖尿病并发症的发生。乙二醛赖氨酸二聚体（GOLD）和甲基乙二醛赖氨酸二聚体（MOLD）此前已被描述为这类反应性二羰基化合物。在此，一种新的化合物3-脱氧葡萄糖酮赖氨酸二聚体（DOLD），即马尿酸赖氨酸与3-脱氧葡萄糖酮反应产生的交联产物，已通过高效液相色谱法分离，并通过质谱和核磁共振确定了其结构。
