Niwa T, Takeda N, Yoshizumi H, Tatematsu A, Ohara M, Tomiyama S, Niimura K
Department of Clinical Laboratory, Nagoya University Branch Hospital, Japan.
Biochem Biophys Res Commun. 1993 Oct 29;196(2):837-43. doi: 10.1006/bbrc.1993.2325.
3-Deoxyglucosone, a potent protein crosslinking intermediate of the Maillard reaction, was first detected in diabetic serum using gas chromatography/mass spectrometry. Serum concentration of 3-deoxyglucosone was elevated in diabetic patients as compared with healthy subjects. More notably, diabetic patients with nephropathy showed higher serum concentration of 3-deoxyglucosone than those without nephropathy. The increased serum concentration of 3-deoxyglucosone in the diabetic patients suggests that 3-deoxyglucosone may be responsible for the development of diabetic complications such as diabetic nephropathy by promoting the formation of advanced glycation end products.
3-脱氧葡萄糖酮是美拉德反应中一种有效的蛋白质交联中间体，它最初是通过气相色谱/质谱法在糖尿病患者血清中检测到的。与健康受试者相比，糖尿病患者血清中3-脱氧葡萄糖酮的浓度升高。更值得注意的是，患有肾病的糖尿病患者血清中3-脱氧葡萄糖酮的浓度高于未患肾病的患者。糖尿病患者血清中3-脱氧葡萄糖酮浓度的升高表明，3-脱氧葡萄糖酮可能通过促进晚期糖基化终产物的形成，导致糖尿病肾病等糖尿病并发症的发生。
