人类线粒体碱基数据库更新
Update of the Human MitBASE database.
作者信息
Attimonelli M, Cooper J M, D'Elia D, de Montalvo A, De Robertis M, Lehväslaiho H, Malladi S B, Memeo F, Stevens K, Schapira A H, Saccone C
机构信息
Dipartimento di Biochimica e Biologia Molecolare, Università degli Studi di Bari, 70126 Bari, Italy.
出版信息
Nucleic Acids Res. 1999 Jan 1;27(1):143-6. doi: 10.1093/nar/27.1.143.
Human MitBASE is a database collecting human mtDNA variants. This database is part of a greater mitochondrial genome database (MitBASE) funded within the EU Biotech Program. The present paper reports the recent improvements in data structure, data quality and data quantity. As far as the database structure is concerned it is now fully designed and implemented. Based on the previously described structure some changes have been made to optimise both data input and data quality. Cross-references with other bio-databases (EMBL, OMIM, MEDLINE) have been implemented. Human MitBASE data can be queried with the MitBASE Simple Query System (http://www.ebi.ac.uk/htbin/Mitbase/mit base.pl) and with SRS at the EBI under the 'Mutation' section (http://srs.ebi.ac.uk/srs5/). At present the HumanMitBASE node contains approximately 5000 variants related to studies investigating population polymorphisms and pathologies.
人类线粒体碱基数据库（Human MitBASE）是一个收集人类线粒体DNA变异的数据库。该数据库是欧盟生物技术计划资助的更大的线粒体基因组数据库（MitBASE）的一部分。本文报告了数据结构、数据质量和数据量方面的最新改进。就数据库结构而言，它现已完全设计并实现。基于先前描述的结构，已进行了一些更改以优化数据输入和数据质量。已实现与其他生物数据库（EMBL、OMIM、MEDLINE）的交叉引用。可通过MitBASE简单查询系统（http://www.ebi.ac.uk/htbin/Mitbase/mit base.pl）以及欧洲生物信息研究所（EBI）的SRS系统在“突变”部分（http://srs.ebi.ac.uk/srs5/）查询人类线粒体碱基数据库的数据。目前，人类线粒体碱基数据库节点包含约5000个与研究群体多态性和病理学相关的变异。
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