MitBASE试点项目：一个关于酿酒酵母中线粒体生物发生及其调控相关核基因的数据库。
MitBASE pilot: a database on nuclear genes involved in mitochondrial biogenesis and its regulation in Saccharomyces cerevisiae.
作者信息
de Pinto B, Malladi S B, Altamura N
机构信息
Consiglio Nazionale delle Ricerche, Centro di Studio sui Mitocondri e Metabolismo Energetico, presso Università di Bari, via Amendola 165/A, I-70126 Bari, Italy.
出版信息
Nucleic Acids Res. 1999 Jan 1;27(1):147-9. doi: 10.1093/nar/27.1.147.
In the framework of the EU BIOTECH PROGRAM and within the 'MITBASE: a comprehensive and integrated database on mtDNA' project, we have prepared a pilot database (MitBASE Pilot) on nuclear genes involved in mitochondrial biogenesis and its regulation in Saccharomyces cerevisiae. MitBASE Pilot includes nuclear genes encoding mitochondrial proteins as well as nuclear genes encoding products which are localised in other sub-cellular compartments but nevertheless interact with mitochondrial functions. Genes have been classified on the basis of the mitochondrial process in which they participate and the mitochondrial phenotype of the gene knockout. The structure of the MitBASE Pilot database has been conceived for a flexible organisation of the information. An intuitive visual query system has been developed which allows users to select information in different combinations, both in the query and the output format, according to their needs. MitBASE Pilot is a relational database, is maintained at the EMBL-European Bioinformatics Institute (EBI) and is available at the World Wide Web site http://www3.ebi.ac. uk/Research/Mitbase/mitbiog.pl
在欧盟生物技术计划框架内，以及在“MITBASE：关于线粒体DNA的综合集成数据库”项目中，我们已针对酿酒酵母中参与线粒体生物合成及其调控的核基因编制了一个试验性数据库（MitBASE试验库）。MitBASE试验库包括编码线粒体蛋白的核基因，以及编码定位于其他亚细胞区室但仍与线粒体功能相互作用的产物的核基因。基因已根据它们所参与的线粒体过程以及基因敲除的线粒体表型进行了分类。MitBASE试验库的结构设计旨在灵活组织信息。已开发出一个直观的可视化查询系统，它允许用户根据自身需求，在查询和输出格式中以不同组合选择信息。MitBASE试验库是一个关系型数据库，由欧洲分子生物学实验室 - 欧洲生物信息学研究所（EBI）维护，可通过万维网站点http://www3.ebi.ac.uk/Research/Mitbase/mitbiog.pl获取。
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