UTRdb：真核生物mRNA 5'和3'非翻译区的专业数据库。
UTRdb: a specialized database of 5' and 3' untranslated regions of eukaryotic mRNAs.
作者信息
Pesole G, Liuni S, Grillo G, Ippedico M, Larizza A, Makalowski W, Saccone C
机构信息
Dipartimento di Biologia, D.B.A.F., Università della Basilicata, via Anzio 10, 85100 Potenza, Italy.
出版信息
Nucleic Acids Res. 1999 Jan 1;27(1):188-91. doi: 10.1093/nar/27.1.188.
Abstract
The 5' and 3' untranslated regions of eukaryotic mRNAs may play a crucial role in the regulation of gene expression controlling mRNA localization, stability and translational efficiency. For this reason we developed UTRdb (http://bigarea.area.ba.cnr.it:8000/BioWWW/#U TRdb), a specialized database of 5' and 3' untranslated sequences of eukaryotic mRNAs cleaned from redundancy. UTRdb entries are enriched with specialized information not present in the primary databases including the presence of nucleotide sequence patterns already demonstrated by experimental analysis to have some functional role. All these patterns have been collected in the UTRsite database so that it is possible to search any input sequence for the presence of annotated functional motifs. Furthermore, UTRdb entries have been annotated for the presence of repetitive elements.
摘要
真核生物mRNA的5'和3'非翻译区可能在基因表达调控中发挥关键作用，控制mRNA的定位、稳定性和翻译效率。因此，我们开发了UTRdb（http://bigarea.area.ba.cnr.it:8000/BioWWW/#UTRdb），这是一个专门的数据库，收录了去除冗余后的真核生物mRNA的5'和3'非翻译序列。UTRdb条目富含初级数据库中不存在的专门信息，包括已通过实验分析证明具有某些功能作用的核苷酸序列模式。所有这些模式都已收集在UTRsite数据库中，以便能够搜索任何输入序列中是否存在注释的功能基序。此外，UTRdb条目还针对重复元件的存在进行了注释。
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