Henikoff J G, Henikoff S, Pietrokovski S
Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109-1024, USA.
Nucleic Acids Res. 1999 Jan 1;27(1):226-8. doi: 10.1093/nar/27.1.226.
Blocks are ungapped multiple sequence alignments representing conserved protein regions, and the Blocks Database consists of blocks from documented protein families. World Wide Web (http://www. blocks.fhcrc.org) and Email (blocks@blocks.fhcrc.org) servers provide tools for homology searching and for analyzing protein family relationships. New enhancements include a multiple alignment processor that extends the use of these tools to imported multiple alignments of families not present in the database and a PCR primer designer that implements a new strategy for gene isolation.
模块是代表保守蛋白质区域的无间隙多序列比对,而模块数据库由来自已记录蛋白质家族的模块组成。万维网(http://www.blocks.fhcrc.org)和电子邮件(blocks@blocks.fhcrc.org)服务器提供了用于同源性搜索和分析蛋白质家族关系的工具。新的增强功能包括一个多序列比对处理器,它将这些工具的使用扩展到对数据库中不存在的家族的导入多序列比对,以及一个实施新基因分离策略的PCR引物设计器。