最近对块数据库服务器的增强。
Recent enhancements to the Blocks Database servers.
作者信息
Henikoff J G, Pietrokovski S, Henikoff S
机构信息
Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, WA 98104, USA.
出版信息
Nucleic Acids Res. 1997 Jan 1;25(1):222-5. doi: 10.1093/nar/25.1.222.
Abstract
The Blocks Database contains multiple alignments of conserved regions in protein families which can be searched by e-mail (blocks@blocks.fhcrc.org) and World Wide Web (http://blocks.fhcrc.org/ ) servers to classify protein and nucleotide sequences. Recent enhancements to the servers include: (i) improved calculation of position-specific scoring matrices from blocks; (ii) availability of the Prints protein fingerprint database for searching in Blocks format; (iii) a representative sequence biased towards the Blocks of a protein family; (iv) a tree constructed from the Blocks of a protein family; (v) links to related World Wide Web pages for a family; and (vi) the new Local Alignment of Multiple Alignments (LAMA) method to search a block against a database of blocks.
摘要
“模块数据库”包含蛋白质家族中保守区域的多个比对结果，可通过电子邮件（blocks@blocks.fhcrc.org）和万维网（http://blocks.fhcrc.org/ ）服务器进行搜索，以对蛋白质和核苷酸序列进行分类。服务器最近的改进包括：（i）改进了从模块计算位置特异性评分矩阵的方法；（ii）提供了可按模块格式搜索的“印记”蛋白质指纹数据库；（iii）偏向于蛋白质家族模块的代表性序列；（iv）由蛋白质家族模块构建的树；（v）指向某个家族相关万维网页的链接；以及（vi）用于在模块数据库中搜索模块的新的多序列比对局部比对（LAMA）方法。
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