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配体门控离子通道数据库

The Ligand Gated Ion Channel Database.

作者信息

Le Novère N, Changeux J P

机构信息

Neurobiologie Moléculaire, URA CNRS 1281, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris cedex 15, France.

出版信息

Nucleic Acids Res. 1999 Jan 1;27(1):340-2. doi: 10.1093/nar/27.1.340.

DOI:10.1093/nar/27.1.340
PMID:9847222
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC148177/
Abstract

The ligand gated ion channels (LGICs) are ionotropic receptors to neurotransmitters. Their physiological effect is carried out by the opening of an ionic channel upon binding of a particular neurotransmitter. These LGICs constitute superfamilies of receptors formed by homologous subunits. A database has been developed to handle the growing wealth of cloned subunits. This database contains nucleic acid sequences, protein sequences, as well as multiple sequence alignments and phylogenetic studies. This database is accessible via the worldwide web (http://www.pasteur.fr/units/neubiomol/LGIC.h tml), where it is continuously updated. A downloadable version is also available [currently v0.1 (98.06)].

摘要

配体门控离子通道（LGICs）是神经递质的离子otropic受体。它们的生理效应是通过特定神经递质结合后离子通道的开放来实现的。这些LGICs由同源亚基构成受体超家族。已经开发了一个数据库来处理不断增加的克隆亚基信息。该数据库包含核酸序列、蛋白质序列以及多序列比对和系统发育研究。该数据库可通过万维网（http://www.pasteur.fr/units/neubiomol/LGIC.html）访问，并且在该网站上会持续更新。也有一个可下载版本[当前版本为v0.1（98.06）]。

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