1型人类免疫缺陷病毒在垂直感染婴儿体内的复制动态
Dynamics of human immunodeficiency virus type 1 replication in vertically infected infants.
作者信息
Luzuriaga K, Wu H, McManus M, Britto P, Borkowsky W, Burchett S, Smith B, Mofenson L, Sullivan J L
机构信息
Department of Pediatrics, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Boston, Massachusetts, USA.
出版信息
J Virol. 1999 Jan;73(1):362-7. doi: 10.1128/JVI.73.1.362-367.1999.
Abstract
Plasma human immunodeficiency virus type 1 (HIV-1) turnover and kinetics were studied in children aged 15 days to 2 years following the initiation of a triple antiretroviral drug regimen consisting of zidovudine, lamivudine, and nevirapine. HIV-1 turnover was at least as rapid as that previously described in adults; turnover rates were more rapid in infants and children aged 3 months to 2 years than in infants less than 3 months of age. These data confirm the central role of HIV-1 replication in the pathogenesis of vertical HIV-1 infection and reinforce the importance of early, potent combination therapies for the long-term control of HIV-1 replication.
摘要
在开始使用由齐多夫定、拉米夫定和奈韦拉平组成的三联抗逆转录病毒药物治疗方案后，对15天至2岁儿童的血浆1型人类免疫缺陷病毒（HIV-1）周转和动力学进行了研究。HIV-1周转至少与先前在成人中描述的一样快；3个月至2岁的婴儿和儿童的周转率比小于3个月的婴儿更快。这些数据证实了HIV-1复制在垂直HIV-1感染发病机制中的核心作用，并强化了早期强效联合治疗对长期控制HIV-1复制的重要性。
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