西索米星和庆大霉素在小鼠针对革兰氏阴性杆菌的保护试验中的活性比较。
Comparison of activity of sisomicin and gentamicin in mouse protection tests with gram-negative bacilli.
作者信息
Meyers B R, Hirschman S Z
出版信息
Antimicrob Agents Chemother. 1976 Aug;10(2):384-6. doi: 10.1128/AAC.10.2.384.
Abstract
The efficacy of sisomicin and gentamicin was compared in mouse protection studies against strains of Escherichia coli, Klebsiella sp., Enterobacter aerogenes, Serratia marcescens, Proteus mirabilis, and Pseudomonas aeruginosa. There was no significant difference in mortality of the mice in any of the protocol groups when five different dosages of sisomicin and gentamicin given by three separate schedules were compared for each bacterial inoculum in each antibiotic protocol. The mean protective dose values of sisomicin were at least one-half those of gentamicin for each protocol against Pseudomonas aeruginosa.
摘要
在针对大肠杆菌、克雷伯菌属、产气肠杆菌、粘质沙雷氏菌、奇异变形杆菌和铜绿假单胞菌菌株的小鼠保护研究中，比较了西索米星和庆大霉素的疗效。在每个抗生素方案中，针对每种细菌接种物，比较了通过三种不同给药方案给予的五种不同剂量的西索米星和庆大霉素时，各方案组小鼠的死亡率无显著差异。在针对铜绿假单胞菌的每个方案中，西索米星的平均保护剂量值至少是庆大霉素的一半。
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