奈替米星的体外抗菌活性及其与西索米星、庆大霉素和妥布霉素的比较。
Antimicrobial activity in vitro of netilmicin and comparison with sisomicin, gentamicin, and tobramycin.
作者信息
Meyers B R, Hirschman S Z
出版信息
Antimicrob Agents Chemother. 1977 Jan;11(1):118-21. doi: 10.1128/AAC.11.1.118.
The antimicrobial activity of netilmicin, a new semisynthetic aminoglycosidic aminocyclitol, was determined against 123 recent gram-negative clinical isolates susceptible to gentamicin and 60 isolates resistant to either sisomicin, gentamicin, or tobramycin. The minimal inhibitory concentrations and minimal bactericidal concentrations of netilmicin, sisomicin, gentamicin, and tobramycin against Pseudomonas, Escherichia coli, Klebsiella, Enterobacter, Proteus mirabilis, and indole-positive Proteus were, in general, quite similar. Gentamicin was the most active against Serratia. A total of 54, 67, and 88% of gentamicin-resistant Pseudomonas, Serratia, and Klebsiella, respectively, were susceptible to netilmicin. Strains of indole-positive Proteus, Acinetobacter, Providencia, and E. coli resistant to gentamicin were likely to be resistant also to netilmicin.
测定了新的半合成氨基糖苷类氨基环醇奈替米星对123株近期对庆大霉素敏感的革兰氏阴性临床分离株以及60株对西索米星、庆大霉素或妥布霉素耐药的分离株的抗菌活性。奈替米星、西索米星、庆大霉素和妥布霉素对铜绿假单胞菌、大肠埃希菌、克雷伯菌属、肠杆菌属、奇异变形杆菌和吲哚阳性变形杆菌的最低抑菌浓度和最低杀菌浓度总体上非常相似。庆大霉素对沙雷菌属的活性最强。分别有54%、67%和88%的对庆大霉素耐药的铜绿假单胞菌、沙雷菌属和克雷伯菌属对奈替米星敏感。对庆大霉素耐药的吲哚阳性变形杆菌、不动杆菌属、普罗威登斯菌属和大肠埃希菌菌株也可能对奈替米星耐药。
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