Mitchell P, Wang J J, Currie J, Cumming R G, Smith W
Department of Ophthalmology, University of Sydney, Westmead Hospital.
Aust N Z J Med. 1998 Oct;28(5):627-32. doi: 10.1111/j.1445-5994.1998.tb00659.x.
Migraine is a common disorder with recently described vascular associations, yet there are few Australian population-based data describing migraine prevalence.
To assess the prevalence and vascular associations with lifetime past history of typical migraine headache in a representative sample of older Australians.
The Blue Mountains Eye Study examined 3654 permanent residents aged 49 or older living in two postcode areas, west of Sydney (82.4% participation) during 1992-4. A structured interview was administered, including questions about past or present history of typical migraine. The diagnosis was consistent with International Headache Society criteria.
A lifetime past history of typical migraine was given by 17% of participants, including 22% of women and 10% of men, a female:male ratio of 2.3:1. A marked trend for declining lifetime migraine frequency with increasing age was found for both sexes. Modest statistically significant associations were found with vascular disease history, after multivariate adjustment, which included vascular risk factors. These associations were stronger in men than in women. Among men, typical migraine was significantly associated with history of angina, odds ratio (OR) 2.0, acute myocardial infarction (OR 1.9) and stroke (OR 2.2). Among women, statistically significant associations were present only with history of myocardial infarct (OR 1.8).
These data indicate similar prevalence rates for lifetime typical migraine history in a representative sample of older Australians, compared to recent US and Canadian populations. Modest, statistically significant associations between typical migraine and past history of vascular disease were found, with the strongest associations found in men.
偏头痛是一种常见疾病，近期有研究描述了其与血管的关联，但澳大利亚基于人群的偏头痛患病率数据较少。
在澳大利亚老年代表性样本中评估典型偏头痛头痛的终生患病率及其与血管的关联。
蓝山眼研究于1992 - 1994年期间对悉尼西部两个邮政编码区域的3654名49岁及以上常住居民进行了检查（参与率82.4%）。进行了结构化访谈，包括有关典型偏头痛过去或现在病史的问题。诊断符合国际头痛协会标准。
17%的参与者有典型偏头痛的终生病史，其中女性占22%，男性占10%，男女比例为2.3:1。发现两性终生偏头痛频率均随年龄增长呈明显下降趋势。多变量调整后（包括血管危险因素），发现与血管疾病史存在适度的统计学显著关联。这些关联在男性中比在女性中更强。在男性中，典型偏头痛与心绞痛病史显著相关，比值比（OR）为2.0，急性心肌梗死（OR 1.9）和中风（OR 2.2）。在女性中，仅与心肌梗死病史存在统计学显著关联（OR 1.8）。
这些数据表明，与近期美国和加拿大人群相比，澳大利亚老年代表性样本中典型偏头痛终生病史的患病率相似。发现典型偏头痛与血管疾病过去病史之间存在适度的统计学显著关联，其中男性的关联最强。
