Boĭtsova L V
Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.
Ukr Biokhim Zh (1978). 1997 Jul-Aug;69(4):99-103.
Dynamics of changes in the peroxide level, contents of reduced and oxidized glutathione, activity of glutathione peroxidase and glutathione reductase in different organs of a rat under the influence of a single injection of embiquine in the dose of 1/2 DL50 was studied. Alkylating antitumor preparation was shown to cause the decrease of glutathione peroxidase and glutathione reductase activity. Activation glutathione antiperoxide system decreased cytotoxic effects of embiquine by prevention of lipoperoxid accumulation in the liver in the nearest periods of investigation after injection of the preparation, and in the kidney and spleen--during the whole period of investigation.
研究了单次注射剂量为1/2 DL50的恩比喹对大鼠不同器官中过氧化物水平、还原型和氧化型谷胱甘肽含量、谷胱甘肽过氧化物酶和谷胱甘肽还原酶活性变化的动力学。结果表明，烷基化抗肿瘤制剂可导致谷胱甘肽过氧化物酶和谷胱甘肽还原酶活性降低。激活谷胱甘肽抗过氧化物系统可通过在注射制剂后的最近研究期间防止肝脏中脂质过氧化积累，以及在整个研究期间防止肾脏和脾脏中脂质过氧化积累，来降低恩比喹的细胞毒性作用。
