Bygrave H A, Geh J I, Jani Y, Glynne-Jones R
Mount Vernon Hospital, Northwood, Middlesex, UK.
Clin Oncol (R Coll Radiol). 1998;10(5):334-6. doi: 10.1016/s0936-6555(98)80093-9.
Neurological complications of 5-fluorouracil (5-FU) chemotherapy are uncommon events. The two patients presented demonstrate two manifestations of 5-FU neurotoxicity, namely a cerebellar syndrome in association with global motor weakness and bulbar palsy, and a bilateral third cranial (oculomotor) nerve palsy. Both highlight the rapid onset and severity of these unusual side effects but also emphasize that, unlike paraneoplastic syndromes or central nervous system involvement by tumour, complete spontaneous recovery is a potential outcome.
5-氟尿嘧啶（5-FU）化疗的神经并发症并不常见。所呈现的这两名患者展示了5-FU神经毒性的两种表现形式，即伴有全身性运动无力和延髓麻痹的小脑综合征，以及双侧动眼神经麻痹。两者都凸显了这些不寻常副作用的快速发作和严重性，但也强调，与副肿瘤综合征或肿瘤累及中枢神经系统不同，完全自发恢复是一种可能的结果。
