Bixenman W W, Nicholls J V, Warwick O H
Am J Ophthalmol. 1977 Jun;83(6):789-93. doi: 10.1016/0002-9394(77)90904-7.
Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity. The neurotoxicity was associated with oculomotor disturbances expressed primarily as weakness of convergence and divergence. Detailed postmortem examination of one patient revealed no anatomical abnormalities of the central nervous system. The ocular motor disturbances are probably an expression of regional 5-FU neurotoxicity primarily affecting the brain stem.
两名接受5-氟尿嘧啶（5-FU）治疗的播散性结肠癌患者出现了典型的5-FU神经毒性所致的小脑功能障碍。这种神经毒性与眼球运动障碍有关，主要表现为集合和散开功能减弱。对其中一名患者进行的详细尸检未发现中枢神经系统存在解剖学异常。眼球运动障碍可能是主要影响脑干的局部5-FU神经毒性的一种表现。
