Smith F E, Sweet D E, Brunner C M, Davis J S
Ann Rheum Dis. 1976 Jun;35(3):227-32. doi: 10.1136/ard.35.3.227.
Recent reports of avascular necrosis (AN) in systemic lupus erythematosus (SLE) have suggested that its occurrence may be most frequent in young patients. In our population of 99 patients with SLE, 7 young patients have developed AN. Patterns of prednisone therapy had no apparent relationship to the development of AN. AN may become apparent in patients who have relatively inactive lupus, when increased physical activity precipitates articular collapse. A diagnosis of AN should be considered in young patients with localized joint pain.
近期有关系统性红斑狼疮（SLE）中无血管性坏死（AN）的报告表明，其发病在年轻患者中可能最为常见。在我们99例SLE患者群体中，有7例年轻患者发生了AN。泼尼松治疗模式与AN的发生无明显关联。当身体活动增加促使关节塌陷时，AN可能在狼疮相对不活跃的患者中显现出来。对于有局部关节疼痛的年轻患者，应考虑AN的诊断。
