胆结石与异氟烷肝炎

Gallstones and isoflurane hepatitis.

作者信息

Meldrum D J, Griffiths R, Kenna J G

机构信息

Department of Anaesthesia, Hinchingbrooke Hospital, Huntingdon, UK.

出版信息

Anaesthesia. 1998 Sep;53(9):905-9. doi: 10.1046/j.1365-2044.1998.00567.x.

DOI:10.1046/j.1365-2044.1998.00567.x

PMID:9849287

Abstract

This report is of a case of a previously fit 65-year-old woman who developed postoperative liver dysfunction following an anaesthetic involving isoflurane. Biliary ultrasound demonstrated gallstones. However, serum antibodies to trifluoroacetylated proteins were detected, suggesting that immune sensitisation to the anaesthetic could have contributed to the impaired liver function.

摘要

本报告介绍了一例病例，患者为一名65岁既往健康的女性，在接受异氟烷麻醉后出现术后肝功能障碍。胆道超声显示有胆结石。然而，检测到血清中存在针对三氟乙酰化蛋白的抗体，提示对该麻醉剂的免疫致敏可能导致了肝功能受损。