鸡蛋花茎部粗生物碱部位的神经药理学活性

Neuropharmacological activities of the crude alkaloidal fraction from stems of Tabernaemontana pandacaqui Poir.

作者信息

Taesotikul T, Panthong A, Kanjanapothi D, Verpoorte R, Scheffer J J

机构信息

Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Thailand.

出版信息

J Ethnopharmacol. 1998 Oct;62(3):229-34. doi: 10.1016/s0378-8741(98)00081-6.

DOI:10.1016/s0378-8741(98)00081-6

PMID:9849633

Abstract

The crude alkaloidal (CA) fraction from the stem of Tabernaemontana pandacaqui Poir. was studied for its pharmacological activity on the central nervous system (CNS) of animals. The CA fraction was found to produce symptoms of CNS depression in conscious rats and mice, viz. reduction in spontaneous motility, potentiation of pentobarbital sleeping time, prolongation of latency of convulsions induced by pentylenetetrazole and antinociception. However, the fraction could not antagonize oxotremorine-induced tremor. The observations suggest that the CA fraction possesses a CNS depressant activity.

摘要

对来自糖胶树（Tabernaemontana pandacaqui Poir.）茎部的粗生物碱（CA）组分进行了研究，以考察其对动物中枢神经系统（CNS）的药理活性。发现CA组分可使清醒大鼠和小鼠产生中枢神经系统抑制症状，即自发活动减少、戊巴比妥睡眠时间延长、戊四氮诱导惊厥的潜伏期延长以及抗伤害感受。然而，该组分不能拮抗氧化震颤素诱导的震颤。这些观察结果表明，CA组分具有中枢神经系统抑制活性。