Daeppen J B, Krieg M A, Burnand B, Yersin B
University Institute of Social and Preventive Medicine, Alcohol Multidisciplinary Unit, Lausanne University Medical School, Switzerland.
Am J Drug Alcohol Abuse. 1998 Nov;24(4):685-94. doi: 10.3109/00952999809019617.
Health-related quality of life (HRQoL) was evaluated in a sample of alcohol-dependent patients with the 36-item Medical Outcome Study Short-Form Health Survey (MOS-SF-36). The instrument was administered to 147 patients (77% males), aged 26-78, with a DSM-III-R diagnosis of alcohol dependence. The Hamilton Depression Scale (HDS), the Severity of Alcohol Dependence Questionnaire (SADQ), and the Addiction Severity Index (ASI) were also administered to the first 100 patients included in the study. The reliability and validity of the MOS-SF-36 were evaluated. Test-retest intraclass coefficients for a 10-day interval were in the range .65 to .79, whereas the Cronbach alpha coefficient indicated good internal consistency (range .70 to .89). Compared to scores observed in the general population, MOS-SF-36 scores for alcohol-dependent patients were relatively low (indicating worse perception of HRQoL), especially in the psychological and role dimensions (range 52/100 to 55/100), but were closer to populational values in the physical and functional dimensions (range 61/100 to 75/100)). The highest correlation between MOS-SF-36 dimensions and HDS was found in the MOS-SF-36 "mental health" dimension (r=-.56, p < .001); this dimension was also correlated highly with the psychiatric dimension of the ASI (r=-.73, p < .001). The eight dimensions of the MOS-SF-36 were 21% to 127% lower in patients with HDS greater than or equal to 16 (major depression) compared to those with HDS less than or equal to 7 (absence of depression). The MOS-SF-36 dimensions were 10% to 141% lower in patients with high "ASI alcohol" scores, indicating worse HRQoL profiles with a higher severity of alcohol dependence. The MOS-SF-36 presents good criteria for reliability and validity in alcohol-dependent patients. The results suggested that alcohol-dependent patients perceived their problems more as psychological than physical. The severity of alcohol dependence and depression seemed to influence the perception of HRQoL negatively.
采用36项医学结局研究简明健康调查问卷（MOS-SF-36）对酒精依赖患者样本的健康相关生活质量（HRQoL）进行了评估。该问卷被施用于147名年龄在26至78岁之间、根据《精神疾病诊断与统计手册》第三版修订本（DSM-III-R）诊断为酒精依赖的患者（77%为男性）。还对纳入研究的前100名患者施行了汉密尔顿抑郁量表（HDS）、酒精依赖严重程度问卷（SADQ）和成瘾严重程度指数（ASI）。对MOS-SF-36的信度和效度进行了评估。10天间隔的重测组内系数在0.65至0.79之间，而克朗巴哈α系数表明其具有良好的内部一致性（范围为0.70至0.89）。与普通人群中观察到的分数相比，酒精依赖患者的MOS-SF-36分数相对较低（表明对HRQoL的感知较差），尤其是在心理和角色维度（范围为52/100至55/100），但在身体和功能维度上更接近人群值（范围为61/100至75/100）。MOS-SF-36维度与HDS之间的最高相关性出现在MOS-SF-36的“心理健康”维度（r = -0.56，p < 0.001）；该维度也与ASI的精神科维度高度相关（r = -0.73，p < 0.001）。与汉密尔顿抑郁量表得分小于或等于7（无抑郁）的患者相比，汉密尔顿抑郁量表得分大于或等于16（重度抑郁）的患者，MOS-SF-36的八个维度低21%至127%。“ASI酒精”得分高的患者，MOS-SF-36维度低10%至141%，表明酒精依赖严重程度越高，HRQoL状况越差。MOS-SF-36在酒精依赖患者中具有良好的信度和效度标准。结果表明，酒精依赖患者更多地将他们的问题视为心理问题而非身体问题。酒精依赖和抑郁的严重程度似乎对HRQoL的感知有负面影响。
