Oviasu E, Famodu A A, Ojeh E A
Department of Medicine, University of Benin Teaching Hospital, Benin City, Nigeria.
Clin Hemorheol Microcirc. 1998 Oct;19(2):163-7.
A simple and reproducible 'syringe viscometer' method was used to determine plasma viscosity, an important haemorheological parameter, in 27 (14 M, 13 F) nephrotic Nigerian patients. The plasma fibrinogen (PFC) and immunoglobulin levels (IgG, IgM, IgA) were also determined in these patients. Similar determinations were carried out in 30 (15 M, 15 F) age- and sex-matched healthy control subjects for comparison. The nephrotic patients had significantly higher relative plasma viscosity (RPV), PFC and IgM levels (2.02+/-0.17 vs. 1.66+/-0.19, 6.48+/-2.59 vs. 2.26+/-0.91 g/l; 316.2+/-169.0 vs. 186.0+/-59.5 IU/ml, p < 0.001, respectively). However, IgG and IgA levels were significantly less (151.1+/-88.7 vs. 205.7+/-77.6 IU/ml, p < 0.05, and 95.8+/-41.5 vs. 127.3+/-31.3 IU/ml, p < 0.01, respectively). In the nephrotic patients, plasma fibrinogen and IgM levels had a significant positive correlation with RPV (r=0.444, p < 0.05, and r=0.452, p < 0.02, respectively). The observed increased plasma viscosity in our nephrotic patients could on the long term predispose them to increased risk for cardiovascular morbidity.
采用一种简单且可重复的“注射器粘度计”方法，对27名（14名男性，13名女性）尼日利亚肾病患者进行了血浆粘度（一项重要的血液流变学参数）测定。还测定了这些患者的血浆纤维蛋白原（PFC）和免疫球蛋白水平（IgG、IgM、IgA）。为作比较，对30名（15名男性，15名女性）年龄和性别匹配的健康对照者进行了类似测定。肾病患者的相对血浆粘度（RPV）、PFC和IgM水平显著更高（分别为2.02±0.17对1.66±0.19、6.48±2.59对2.26±0.91 g/l；316.2±169.0对186.0±59.5 IU/ml，p均<0.001）。然而，IgG和IgA水平显著更低（分别为151.1±88.7对205.7±77.6 IU/ml，p<0.05；95.8±41.5对127.3±31.3 IU/ml，p<0.01）。在肾病患者中，血浆纤维蛋白原和IgM水平与RPV呈显著正相关（r分别为0.444，p<0.05；r为0.452，p<0.02）。我们观察到肾病患者血浆粘度升高，从长远来看，这可能使他们患心血管疾病的风险增加。
