Stegmann G F
Department of Surgery, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
J S Afr Vet Assoc. 1998 Sep;69(3):89-92. doi: 10.4102/jsava.v69i3.823.
Midazolam hydrochloride administered intramuscularly at a dosage of 0.4 mg/kg induced sedation and sternal recumbency in goats. Increasing the dosage to 1 mg/kg resulted in rapid onset of ataxia followed by lateral recumbency, and loss of consciousness. Light surgical anaesthesia lasted for a period of 7-15 min and was suitable for non-painful procedures. Heart rate was significantly increased (p < 0.05) at both dosage rates, while respiration rate was only increased after midazolam at 0.4 mg/kg. The combination of midazolam (0.4 mg/kg) and ketamine hydrochloride (4 mg/kg) increased heart and respiration rate significantly (p < 0.05). A light plane of surgical anaesthesia suitable for endotracheal intubation was induced, which lasted for a period of 16-39 min.
以0.4毫克/千克的剂量肌肉注射盐酸咪达唑仑可使山羊产生镇静作用并使其呈胸骨卧位。将剂量增加到1毫克/千克会导致共济失调迅速发作，随后出现侧卧和意识丧失。轻度外科麻醉持续7至15分钟，适用于无痛手术。两种剂量率下心率均显著增加（p<0.05），而仅在0.4毫克/千克的咪达唑仑注射后呼吸频率才增加。咪达唑仑（0.4毫克/千克）与盐酸氯胺酮（4毫克/千克）联合使用可显著增加心率和呼吸频率（p<0.05）。诱导出了适合气管插管的轻度外科麻醉平面，持续时间为16至39分钟。
