Vasei M, Kumar P V, Malekhoseini S A, Kadivar M
Department of Pathology, Shiraz Medical School, Iran.
Acta Cytol. 1998 Nov-Dec;42(6):1437-40. doi: 10.1159/000332181.
Papillary Hürthle cell carcinoma with lymphoplasmacytic stroma is a newly recognized variant of papillary carcinoma of the thyroid gland. Fine needle aspiration findings reveal some points that have not been reported previously.
A 50-year-old female presented with a left lobe thyroid mass. Fine needle aspiration of the nodule yielded cellular smears, mostly in large and small papillary clusters of Hürthle cells, with nuclear grooves and rare nuclear inclusions in a lymphoplasmacytic background. Isolated Hürthle cell and multinucleated giant cells were also seen. Histopathologic examination of the 3-cm-diameter nodule showed papillary Hürthle cell carcinoma with lymphocytic stroma, or "Warthin-like tumor" of the thyroid, with capsular invasion.
The presence of papillary clusters with nuclear features of papillary carcinoma and oxyphilic cytoplasm in a lymphoplasmacytic background should raise the diagnosis of Warthin-like tumor of the thyroid.
伴有淋巴浆细胞性间质的乳头状许特莱细胞癌是甲状腺乳头状癌一种新认识的变异型。细针穿刺活检结果揭示了一些以前未报道过的要点。
一名50岁女性，表现为左叶甲状腺肿块。对该结节进行细针穿刺活检，获得细胞涂片，主要为许特莱细胞的大小不等的乳头状细胞簇，在淋巴浆细胞背景中可见核沟及罕见的核内包涵体。还可见单个许特莱细胞及多核巨细胞。对直径3厘米的结节进行组织病理学检查显示为伴有淋巴细胞性间质的乳头状许特莱细胞癌，即甲状腺的“沃辛瘤样肿瘤”，伴包膜侵犯。
在淋巴浆细胞背景中出现具有乳头状癌核特征及嗜酸性细胞质的乳头状细胞簇应考虑甲状腺沃辛瘤样肿瘤的诊断。
