Katayama S, Ohshita J, Sugaya K, Hirano M, Momose Y, Yamamura S
Department of Pharmacy, Japan Medical Hospital, Tokyo, Japan.
Int J Mol Med. 1998 Dec;2(6):675-9. doi: 10.3892/ijmm.2.6.675.
We formulated de novo a poraprezinc-sodium alginate suspension (P-AG) as a specific treatment for severe gingivostomatitis and administered it to 15 patients who had developed such inflammation while on chemotherapy. Very high utility of P-AG was demonstrated and the response was classified as excellent in 10 patients and good in 5 patients. The mechanism of the beneficial effect of P-AG in treatment of severe gingivostomatitis accompanied by hemorrhagic erosion and ulcers is considered to involve the mucosal protective effect, free radical scavenging activity and tissue repair promoting action of poraprezinc together with the hemostatic action of sodium alginate.
我们新配制了一种聚锌藻酸钠悬浮液（P-AG）作为重度龈口炎的特效治疗药物，并将其应用于15例化疗期间发生此类炎症的患者。结果显示P-AG具有很高的效用，10例患者的反应为优，5例为良。P-AG对伴有出血性糜烂和溃疡的重度龈口炎的有益治疗作用机制被认为涉及聚锌藻的黏膜保护作用、自由基清除活性和组织修复促进作用，以及藻酸钠的止血作用。
