Felice K J, North W A
Department of Neurology, University of Connecticut School of Medicine, Farmington 06030, USA.
J Neurol Sci. 1998 Oct;160 Suppl 1:S30-2. doi: 10.1016/s0022-510x(98)00195-6.
Serum creatine kinase (CK1) values were recorded while or soon after the diagnosis of amyotrophic lateral sclerosis (ALS) was established in 140 of 217 (65%) consecutive patients seen in the Motor Neuron Disease Clinic at this center during a 5-year period. Second creatine kinase (CK2) determinations were recorded on 48 of 140 (34%) ALS patients later in the course of the disease. The mean CK1 and CK2 values (unit, times the upper limit of normal) were 1.22 (range, 0.1 to 3.0; median, 0.80) and 1.34 (range, 0.1-9.2; median, 0.80) (P=0.11, r=0.92, mean difference=28.2%). Of the 140 ALS patients, 58 (41%) (male:female ratio: 2.9:1.0) had elevated CK1 values ranging from 1.03 to 13.0 (mean, 2.21; median, 1.67). Twelve patients (8.6%) had CK1 values greater than 3.0. Mean CK1 values were significantly greater (P=0.001) in male (mean, 1.56) versus female (mean, 0.80) ALS patients, and significantly greater (P=0.009) in limb-onset (mean, 1.34) versus bulbar-onset (mean, 0.80) disease. CK1 values correlated poorly with and were not predictive of age of onset or survival.
在该中心运动神经元疾病诊所5年期间连续就诊的217例患者中，有140例（65%）在确诊肌萎缩侧索硬化症（ALS）时或确诊后不久记录了血清肌酸激酶（CK1）值。在疾病后期，对140例ALS患者中的48例（34%）进行了第二次肌酸激酶（CK2）测定。CK1和CK2的平均值（单位：正常上限倍数）分别为1.22（范围：0.1至3.0；中位数：0.80）和1.34（范围：0.1 - 9.2；中位数：0.80）（P = 0.11，r = 0.92，平均差异 = 28.2%）。在140例ALS患者中，58例（41%）（男女比例为2.9:1.0）的CK1值升高，范围为1.03至13.0（平均为2.21；中位数为1.67）。12例患者（8.6%）的CK1值大于3.0。男性ALS患者的平均CK1值（平均为1.56）显著高于女性（平均为0.80）（P = 0.001），肢体起病型患者的平均CK1值（平均为1.34）显著高于延髓起病型患者（平均为0.80）（P = 0.009）。CK1值与发病年龄或生存率的相关性较差，且不能预测发病年龄或生存率。
