Larsson H, Elmståhl S, Berglund G, Ahrén B
Department of Medicine, Lund University, Malmö University Hospital, Sweden.
J Clin Endocrinol Metab. 1998 Dec;83(12):4382-5. doi: 10.1210/jcem.83.12.5342.
The adipocyte hormone leptin regulates body weight in mice by decreasing food intake and increasing energy expenditure. Whether leptin is of physiological importance for these processes in humans is, however, not clear. We therefore studied the relation between leptin and habitual food intake in 64 healthy postmenopausal women. Dietary habits were assessed with a modified diet history method. Body fat content was measured using bioelectrical impedance. In the 64 women, aged 58.6+/-0.4 yr (mean+/-SD), serum leptin was 19.3+/-12.7 ng/mL, body mass index was 25.0+/-3.5 kg/m2, body fat content was 31.6+/-4.3%, fasting glucose was 4.6+/-0.5 mmol/L, and fasting insulin was 56+/-21 pmol/L. Leptin levels were negatively correlated to total energy intake (r=-0.34; P=0.006), carbohydrate intake (r=-0.36; P=0.004), and total (r=-0.27; P=0.034) as well as saturated fat intake (r=-0.31; P=0.014). Leptin was correlated to the absolute, but not to the percent, intake of these nutrients. When normalized for body fat content, the correlations remained significant. Our results suggest that plasma leptin is involved in the physiological regulation of food intake in humans, and that leptin is related to the quantity rather than the quality of habitual food intake.
脂肪细胞激素瘦素通过减少食物摄入量和增加能量消耗来调节小鼠体重。然而，瘦素对人类这些过程是否具有生理重要性尚不清楚。因此，我们研究了64名健康绝经后女性中瘦素与习惯性食物摄入量之间的关系。饮食习惯采用改良的饮食史方法进行评估。使用生物电阻抗测量身体脂肪含量。在这64名年龄为58.6±0.4岁（均值±标准差）的女性中，血清瘦素为19.3±12.7 ng/mL，体重指数为25.0±3.5 kg/m²，身体脂肪含量为31.6±4.3%，空腹血糖为4.6±0.5 mmol/L，空腹胰岛素为56±21 pmol/L。瘦素水平与总能量摄入量（r = -0.34；P = 0.006）、碳水化合物摄入量（r = -0.36；P = 0.004）以及总脂肪摄入量（r = -0.27；P = 0.034）和饱和脂肪摄入量（r = -0.31；P = 0.014）呈负相关。瘦素与这些营养素的绝对摄入量相关，但与百分比摄入量无关。当以身体脂肪含量进行标准化后，相关性仍然显著。我们的结果表明血浆瘦素参与了人类食物摄入的生理调节，并且瘦素与习惯性食物摄入的量而非质量有关。
