Karhunen L J, Lappalainen R I, Haffner S M, Valve R H, Tuorila H, Miettinen H, Uusitupa M I
Department of Clinical Nutrition, University of Kuopio, Finland.
Int J Obes Relat Metab Disord. 1998 Aug;22(8):819-21. doi: 10.1038/sj.ijo.0800657.
To examine the association of leptin with food intake and preferences for sugar and fat in obese humans.
Food intake and preferences for sugar and fat were measured in 35 obese women by a four-day food record and three hedonic tests, respectively.
High fasting serum leptin concentration adjusted for body fat mass and dietary underreporting was associated with low dietary energy and fat intakes. In addition, trends towards lower preference for chocolate as well as for the taste of high-fat, low-sugar mixture were observed in those with higher leptin concentration.
High serum leptin concentration could be associated in obese women with lower dietary energy and fat intakes, and possibly with the lower preference for fat. These findings need to be verified in further human studies.
研究肥胖人群中瘦素与食物摄入量以及对糖和脂肪的偏好之间的关联。
通过为期四天的食物记录和三项享乐测试，分别测量了35名肥胖女性的食物摄入量以及对糖和脂肪的偏好。
在根据体脂量和饮食报告不足情况进行调整后，空腹血清瘦素浓度较高与低饮食能量和脂肪摄入量相关。此外，在瘦素浓度较高的人群中，观察到对巧克力以及高脂肪、低糖混合物味道的偏好有降低的趋势。
肥胖女性中血清瘦素浓度较高可能与较低的饮食能量和脂肪摄入量相关，并且可能与对脂肪的较低偏好有关。这些发现需要在进一步的人体研究中得到验证。
