Clarke N D, Berg J M
Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Science. 1998 Dec 11;282(5396):2018-22. doi: 10.1126/science.282.5396.2018.
More than 3 percent of the protein sequences inferred from the Caenorhabditis elegans genome contain sequence motifs characteristic of zinc-binding structural domains, and of these more than half are believed to be sequence-specific DNA-binding proteins. The distribution of these zinc-binding domains among the genomes of various organisms offers insights into the role of zinc-binding proteins in evolution. In addition, the complete genome sequence of C. elegans provides an opportunity to analyze, and perhaps predict, pathways of transcriptional regulation.
从秀丽隐杆线虫基因组推断出的蛋白质序列中，超过3%含有锌结合结构域特有的序列基序，其中一半以上被认为是序列特异性DNA结合蛋白。这些锌结合结构域在各种生物基因组中的分布，为了解锌结合蛋白在进化中的作用提供了线索。此外，秀丽隐杆线虫的全基因组序列为分析乃至预测转录调控途径提供了契机。
