Hayata T, Uochi T, Asashima M
Department of Life Sciences (Biology), Graduate School of Arts and Sciences, Tokyo, Japan.
Gene. 1998 Oct 9;221(1):159-66. doi: 10.1016/s0378-1119(98)00414-4.
We report the isolation and characterization of a Xenopus sequence, XNLRR-1, that is closely related to a gene for mouse neuronal leucine-rich repeat protein (NLRR-1). The cDNA clone is 4179 bp long and encodes a putative transmembrane glycoprotein of 718 amino acids, containing 12 leucine-rich repeats followed by one C2-type immunoglobulin-like domain and one fibronectin type-III repeat. XNLRR-1 is transcribed mainly in the developing eye area and the ventricular zone from diencephalon to hindbrain and slightly in spinal cord in Xenopus tadpoles. The similarity of the XNLRR-1 gene to other known cell adhesion molecules, together with the expression pattern, suggests that XNLRR-1 is involved in interactions at the neuronal cell surface.
我们报告了非洲爪蟾序列XNLRR-1的分离和特性，该序列与小鼠神经元富含亮氨酸重复蛋白（NLRR-1）的基因密切相关。cDNA克隆长4179 bp，编码一个由718个氨基酸组成的假定跨膜糖蛋白，包含12个富含亮氨酸的重复序列，随后是一个C2型免疫球蛋白样结构域和一个纤连蛋白III型重复序列。XNLRR-1主要在非洲爪蟾蝌蚪发育中的眼部区域以及从间脑到后脑的脑室区转录，在脊髓中也有少量转录。XNLRR-1基因与其他已知细胞粘附分子的相似性以及表达模式表明，XNLRR-1参与神经元细胞表面的相互作用。
