Whitley R J, Shukla S, Crooks R J
Department of Pediatrics, Microbiology, and Medicine, University of Alabama at Birmingham 35233, USA.
J Infect Dis. 1998 Nov;178 Suppl 1:S71-5. doi: 10.1086/514274.
Demographic and clinical characteristics of patients with herpes zoster at the time of presentation predict the duration and severity of pain on long-term follow-up. Analyses by Cox's proportional hazard models of six databases from controlled trials of antiviral drugs (total subjects = 2367) identified covariates for zoster-associated pain; all tests for significance were two-sided. Age strongly influenced pain outcome: patients > or = 50 years old were significantly more likely to have prolonged zoster-associated pain compared with those < 30 years old. Patients with prodromal symptoms or moderate or severe pain at presentation were also more likely to experience prolonged zoster-associated pain. Neither time to initiating treatment after rash onset nor sex of patient influenced pain outcome. Advancing age, prodromal symptoms, and acute pain severity at presentation predicted those individuals most at risk of prolonged pain and postherpetic neuralgia. When two or more of these factors were present, the risk of persistent pain was increased.
带状疱疹患者就诊时的人口统计学和临床特征可预测长期随访时疼痛的持续时间和严重程度。通过对六个来自抗病毒药物对照试验数据库（总受试者 = 2367）进行Cox比例风险模型分析，确定了带状疱疹相关性疼痛的协变量；所有显著性检验均为双侧检验。年龄对疼痛结局有强烈影响：与年龄小于30岁的患者相比，年龄大于或等于50岁的患者发生带状疱疹相关性疼痛延长的可能性显著更高。就诊时有前驱症状或中度或重度疼痛的患者也更有可能经历带状疱疹相关性疼痛延长。皮疹发作后开始治疗的时间和患者性别均未影响疼痛结局。年龄增长、前驱症状和就诊时的急性疼痛严重程度可预测那些最有可能发生疼痛延长和带状疱疹后神经痛的个体。当存在两个或更多这些因素时，持续性疼痛的风险会增加。
