Irwin M, Costlow C, Williams H, Artin K H, Chan C Y, Stinson D L, Levin M J, Hayward A R, Oxman M N
VA Medical Center, University of California, San Diego, USA.
J Infect Dis. 1998 Nov;178 Suppl 1:S104-8. doi: 10.1086/514272.
The incidence of herpes zoster increases markedly with advancing age, and this appears to be causally related to an age-dependent decline in varicella-zoster virus (VZV)-specific cellular immunity. Psychologic stress has also been linked to the occurrence of herpes zoster, but the mechanism involved has not been investigated. This study examined the relationship between major depression and VZV-specific cellular immunity by comparing VZV-specific responder cell frequency (RCF) in adults with major depression (n = 11) to that in age- and sex-matched nondepressed controls (n = 11) and in a larger group of nondepressed adults who were > or = 60 years old. VZV-specific RCF in depressed patients was markedly reduced compared with the RCF in matched controls (t = 2.7, P < .02). In fact, the levels of VZV-specific RCF in the depressed patients were comparable in magnitude to the low levels found in adults > or = 60 years of age. These data indicate that major depression is associated with a marked decline in VZV-specific cellular immunity.
带状疱疹的发病率随年龄增长而显著增加，这似乎与水痘 - 带状疱疹病毒（VZV）特异性细胞免疫随年龄增长而下降存在因果关系。心理压力也与带状疱疹的发生有关，但其中涉及的机制尚未得到研究。本研究通过比较重度抑郁症成年人（n = 11）与年龄和性别匹配的非抑郁症对照组（n = 11）以及年龄≥60岁的更大规模非抑郁症成年人群体中VZV特异性反应细胞频率（RCF），来研究重度抑郁症与VZV特异性细胞免疫之间的关系。与匹配对照组的RCF相比，抑郁症患者的VZV特异性RCF显著降低（t = 2.7，P <.02）。事实上，抑郁症患者的VZV特异性RCF水平与年龄≥60岁成年人中发现的低水平相当。这些数据表明，重度抑郁症与VZV特异性细胞免疫的显著下降有关。
