阿司匹林在冠状动脉疾病中的有益作用并不局限于其血小板抑制作用。
Salutary effects of aspirin in coronary artery disease are not limited to its platelet inhibitory effects.
作者信息
Mehta J L
机构信息
Division of Cardiology, University of Florida College of Medicine, Gainesville 32610-0277, USA.
出版信息
Clin Cardiol. 1998 Dec;21(12):879-84. doi: 10.1002/clc.4960211204.
Aspirin is widely used in the treatment and prevention of coronary artery disease (CAD). However, other platelet inhibitory agents, which inhibit platelet activation, have not been found to be effective or as effective as aspirin. The discrepancy between the efficacy of these compounds and aspirin suggests that the therapeutic efficacy of aspirin may not be limited to its platelet inhibitory effect. In this review, the basis for a unique place for aspirin in the therapy of patients with CAD is discussed. The author believes that the nonplatelet-mediated effects of aspirin could be more important than the platelet inhibitory effect, or at least may complement the platelet inhibitory effects of aspirin in patients with acute myocardial ischemia and in others undergoing intracoronary procedures.
阿司匹林广泛用于冠状动脉疾病（CAD）的治疗和预防。然而，其他抑制血小板活化的血小板抑制剂尚未被发现有效或不如阿司匹林有效。这些化合物与阿司匹林疗效之间的差异表明，阿司匹林的治疗效果可能不限于其血小板抑制作用。在本综述中，讨论了阿司匹林在CAD患者治疗中占据独特地位的依据。作者认为，阿司匹林的非血小板介导作用可能比血小板抑制作用更重要，或者至少在急性心肌缺血患者和其他接受冠状动脉内手术的患者中可能补充阿司匹林的血小板抑制作用。
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