Kristiansson P, Nilsson-Wikmar L, von Schoultz B, Svärdsudd K, Wramsby H
Karolinska Institute, Department of Women and Child Health, Karolinska Hospital, Stockholm, Sweden.
Hum Reprod. 1998 Nov;13(11):3233-8. doi: 10.1093/humrep/13.11.3233.
The influence of ovarian stimulation in in-vitro fertilization (IVF) on the prevalence of back pain with onset during pregnancy was studied in 31 women who became pregnant after IVF treatment and compared with that of 200 spontaneously pregnant women. A two times higher prevalence rate of sacral pain in late pregnancy was reported among IVF pregnant women (P < 0.0001), as well as a significantly higher prevalence rate of positive results of pelvic pain provocation tests performed in late pregnancy (0.0001 < or = P < or = 0.015), as compared with that of the spontaneously pregnant women. Among the IVF pregnant women, there was a significant positive correlation between relaxin concentrations in early pregnancy and the outcome of pelvic pain provocation tests (0.44 < or = r < or = 0.51, P < 0.05). In addition, the serum relaxin concentration was the factor that best explained differences in sacral pain prevalence. When the influence of serum relaxin concentration on back pain prevalence was taken into account, women carrying multiple pregnancies had no more pain than women carrying singletons, and IVF pregnant women had no more pain than spontaneously pregnant women. These results support the hypothesis that relaxin is involved in the generation of pelvic pain in pregnant women.
对31名接受体外受精（IVF）治疗后怀孕的女性，研究了IVF过程中卵巢刺激对孕期出现背痛患病率的影响，并与200名自然受孕女性进行了比较。据报告，与自然受孕女性相比，IVF受孕女性在妊娠晚期骶骨疼痛的患病率高出两倍（P < 0.0001），且在妊娠晚期进行的盆腔疼痛激发试验阳性结果的患病率也显著更高（0.0001 ≤ P ≤ 0.015）。在IVF受孕女性中，妊娠早期松弛素浓度与盆腔疼痛激发试验结果之间存在显著正相关（0.44 ≤ r ≤ 0.51，P < 0.05）。此外，血清松弛素浓度是最能解释骶骨疼痛患病率差异的因素。当考虑血清松弛素浓度对背痛患病率的影响时，多胎妊娠女性的疼痛并不比单胎妊娠女性更多，IVF受孕女性的疼痛也不比自然受孕女性更多。这些结果支持了松弛素参与孕妇盆腔疼痛产生的假说。
