Sawada Y, Seishima M, Funabashi M, Noda T, Maeda M, Kitajima Y
Department of Dermatology, Gifu University School of Medicine, Tsukasamachi 40, Gifu 500-8705, Japan.
Eur J Dermatol. 1998 Oct-Nov;8(7):497-500.
A 49-year-old Japanese woman had been suffering from limited cutaneous scleroderma with papular mucinosis. Papular mucinosis was characterized by multiple, asymptomatic, elevated, skin-colored papules on the dorsal regions of the hands. Histopathological findings of the hard papules showed a marked deposition of hyaluronic acid along sclerosis in the middle and the lower parts of dermis. Serological studies revealed a positive antinuclear antibody (speckled type). Intravenous administration of prostaglandin E1 derivatives reduced the size of the papules, the degree of sclerodactyly and the severity of her Raynaud's phenomenon. These observations suggest that manifestations of scleroderma could be found in some cases of papular mucinosis.
一名49岁的日本女性患有局限性皮肤型硬皮病伴丘疹性黏蛋白病。丘疹性黏蛋白病的特征是双手背部出现多个无症状的、隆起的肤色丘疹。硬丘疹的组织病理学检查结果显示，在真皮中下部的硬化部位有明显的透明质酸沉积。血清学研究显示抗核抗体阳性（斑点型）。静脉注射前列腺素E1衍生物可减小丘疹大小、减轻指端硬化程度并缓解雷诺现象的严重程度。这些观察结果表明，在某些丘疹性黏蛋白病病例中可能会出现硬皮病的表现。
