大鼠肝脏线粒体和微粒体组分中磷脂酸的生物合成。脂肪酸位置特异性的调节。
Phosphatidic acid biosynthesis in rat liver mitochondria and microsomal fractions. Regulation of fatty acid positional specificity.
作者信息
Bjerve K S, Daae L N, Bremer J
出版信息
Biochem J. 1976 Aug 15;158(2):249-54. doi: 10.1042/bj1580249.
Abstract
The positional and fatty acid specificity of phosphatidic acid biosynthesis in rat liver mitochondria and microsomal fractions was studied by using acylcarnitines, CoA and an excess of carnitine palmitoyltransferase (EC 2.3.1.21) as the source of acyl-CoA. In the mitochondria, the preference for palmitic acid at the 1-position is increased at high acyl-CoA concentrations, whereas it is decreased in the microsomal fraction. There was no change in the fatty acid specificity at the 2-position with different acyl-CoA concentrations in any of the factions. The preference in mitochondria for linoleic acid at the 2-position is strongly increased at high concentrations of lysophosphatidic acid.
摘要
利用酰基肉碱、辅酶A以及过量的肉碱棕榈酰转移酶（EC 2.3.1.21）作为酰基辅酶A的来源，研究了大鼠肝脏线粒体和微粒体组分中磷脂酸生物合成的位置特异性和脂肪酸特异性。在线粒体中，高酰基辅酶A浓度下，1位对棕榈酸的偏好性增加，而在微粒体组分中则降低。在任何组分中，不同酰基辅酶A浓度下，2位的脂肪酸特异性均无变化。高浓度溶血磷脂酸时，线粒体中2位对亚油酸的偏好性显著增加。
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Long-chain acyl-CoA synthetase in rat liver. A new assay procedure for the enzyme, and studies on its intracellular localization.大鼠肝脏中的长链脂酰辅酶A合成酶。该酶的一种新检测方法及其细胞内定位研究。
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