SMC蛋白与染色体结构。

SMC proteins and chromosome structure.

作者信息

Strunnikov A V

机构信息

NIH, NICHD, Laboratory of Molecular Embryology, Unit of Chromosome Structure and Function, Bethesda, MD 20892, USA.

出版信息

Trends Cell Biol. 1998 Nov;8(11):454-9. doi: 10.1016/s0962-8924(98)01370-1.

DOI:10.1016/s0962-8924(98)01370-1

PMID:9854313

Abstract

The structure of chromosomes is largely determined by chromosome-associated proteins. Members of the SMC (structural maintenance of chromosomes) family play an important role in both prokaryotic and eukaryotic chromosome structure and dynamics. SMC proteins are involved in chromosome condensation, sister-chromatid cohesion, sex-chromosome dosage compensation, genetic recombination and DNA repair. There have been major advances recently in understanding the function of SMC proteins--including the identification of biochemical activities of SMC-containing protein complexes and the realization that individual SMC proteins might link seemingly unrelated aspects of chromosomal metabolism.

摘要

染色体的结构很大程度上由与染色体相关的蛋白质决定。SMC（染色体结构维持）家族成员在原核生物和真核生物的染色体结构及动态变化中都起着重要作用。SMC蛋白参与染色体浓缩、姐妹染色单体黏连、性染色体剂量补偿、基因重组和DNA修复。最近在理解SMC蛋白的功能方面取得了重大进展，包括鉴定含SMC的蛋白复合物的生化活性，以及认识到单个SMC蛋白可能将染色体代谢中看似不相关的方面联系起来。